El virus del VIH destruye el sistema inmunológico aunque que produce la pérdida de linfocitos T CD4+ en la crimen periférica y los tejidos linfoides. Su ingreso en los linfocitos CD4+ está mediada por la interacción con un receptor de quimiocinas celulares, siendo los más comunes CCR5 y CXCR4. Debido a esto los linfocitos CD4 + activados son
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